Worth mentioning Royton Road Runners - not ladies only, but a small, friendly club that welcomes runners of all standards. Evening runs from Royton Cricket Club at 6.45pm on Mondays & Thursdays.
I've just had a look a look at the womens running network site and all the groups tend to be based around Central Lancs area - Preston, Leyland, Chorley. There are groups in Southport, Wigan and Colne.